Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

Posted Date: Apr 28, 2026
May 28, 2026
Awarded Date: No Awarded Date
SetAside Type
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Solicitation ID Solicitation Title Solicitation Office
ARPA-H-SOL-26-139 Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Synopsis

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.

Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and .... Read More

Office Location Agency Name Solicitation Base Posting Type
NATIONAL INSTITUTES OF HEALTH Combined Synopsis/Solicitation
SetAside Type
No Set aside used
Solicitation ID Solicitation Title Solicitation Office
ARPA-H-SOL-26-139 Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Synopsis

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.

Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and .... Read More

Office Location Agency Name Solicitation Base Posting Type
NATIONAL INSTITUTES OF HEALTH Combined Synopsis/Solicitation
SetAside Type
No Set aside used
Solicitation ID Solicitation Title Solicitation Office
ARPA-H-SOL-26-139 Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)
Synopsis

The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement.

CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure.

Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and .... Read More

Office Location Agency Name Solicitation Base Posting Type
NATIONAL INSTITUTES OF HEALTH Combined Synopsis/Solicitation
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